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Boston Epigenetics Society: Cell-free chromatin sequencing as a new modality in liquid biopsy

Cell-free DNA in human plasma provides access to molecular information about the pathological processes in the organs or tumors from which it originates. These DNA fragments are derived from fragmented chromatin in dying cells, and retain some of the cell of origin histone modifications. Chromatin immunoprecipitation of cell-free nucleosomes followed by sequencing (cfChIP-seq) provides a noninvasive way to unfold the transcriptional states of cells dying within the body, with potential to add an important layers of information to liquid biopsy-based clinical applications. In this talk I will describe the technology, the promise and challenges it presents, and its application in detecting and understanding human disease.

Mar 2, 2023 12:00 PM in Eastern Time (US and Canada)